The knowledge-based ECONOMY is considered as one of the important concepts that has been given special attention in the above-mentioned legal documents of the I. R. Iran, including the general policies of the Resistive ECONOMY. Knowledge-based ECONOMY is a basic need for developing countries such as Iran. Avoiding a knowledge-based ECONOMY greatly reduces competitiveness. Economics based on science and knowledge leads to the sustainable growth and development of society and ultimately the realization of a Resistive ECONOMY. Due to the importance of knowledge-based ECONOMY in the development of the country, the purpose of this study is to "study the current and favorable situation of Iran's ECONOMY based on knowledge-based ECONOMY-Resistive ECONOMY". The type of research is applied-developmental in terms of purpose. Also, in order to determine the current and favorable situation of Iran's ECONOMY based on knowledge-based ECONOMY-Resistive ECONOMY, a questionnaire was developed and analyzed using SPSS software and inferential statistics. The results showed that the situation of the variables "economic and institutional regime", " Information and communication technology" and " Resistive ECONOMY" in Iran in general does not have the desired average. However, the results show that the variables " educated and skilled population" and " innovation system " in Iran have a favorable average. To show the gap between the current and favorable situation of knowledge-based ECONOMY-Resistive ECONOMY variables in Iran, two-sample t-test was used, which according to the results, there is a significant difference between the current and favorable situation of all variables.